长精氨酸胰岛素样生长因子-1 IGF-1 LR3
理化性质
143045-27-6
作用与功效
长效 IGF-1 衍生物：在 IGF-1 基础上 N 端延长 13 个氨基酸并将第 3 位谷氨酸替换为精氨酸，显著降低与 IGFBP 结合、半衰期延长至约 20–30 小时；强效激活 IGF-1R（PI3K/AKT 与 MAPK 通路）促进细胞增殖
功效：超强细胞增殖；极速肌肉增长、软组织修复；同时刺激各类细胞增殖，潜在促肿瘤风险；严格赛事违禁品。
英文详细资料 / Details (EN)
Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1). The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).
The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.
Source: English Wikipedia, "IGF-1 LR3".
功效：超强细胞增殖；极速肌肉增长、软组织修复；同时刺激各类细胞增殖，潜在促肿瘤风险；严格赛事违禁品。