Cagrilintide Dosing Protocol: 10 mg Vial — Week-by-Week Titration & Supplies
给药方案详解
以下方案内容整理自公开资料与临床文献，仅供研究参考，不构成医疗建议。
Quickstart highlights
Cagrilintide 2.4 mg once weekly combined with semaglutide 2.4 mg (CagriSema) produced 22.7% body weight reduction at 68 weeks in the Phase 3 REDEFINE-1 interim analysis, surpassing both monotherapies.
- Concentration: 5 mg/mL (10 mg vial + 2 mL bacteriostatic water).
- At 5 mg/mL: 0.25 mg = 5 units, 0.5 mg = 10 units, 1 mg = 20 units, 2.4 mg = 48 units.
- REDEFINE-1 Phase 3: CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) produced 22.7% weight loss at 68 weeks.
- One 10 mg vial provides ~4 maintenance doses at 2.4 mg weekly.
- Refrigerate; use within 28 days.
Dosing table
For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.
| Week | Dose (µg) | Units | Frequency | Notes |
|---|---|---|---|---|
| 1-4 | 250 | 5 | Once weekly | 0.25 mg — 5 units at 5 mg/mL; one 10 mg vial provides 40 starting doses |
| 5-8 | 500 | 10 | Once weekly | 0.5 mg — 10 units |
| 9-12 | 1000 | 20 | Once weekly | 1 mg — 20 units |
| 13-16 | 1700 | 34 | Once weekly | 1.7 mg — 34 units |
| 17+ | 2400 | 48 | Once weekly | 2.4 mg maintenance — 48 units; 10 mg vial provides ~4 maintenance doses |
Your free Cagrilintide tracker
- Dose reminders
- Injection logging
- Cycle progress
Reconstitution steps
- Draw 2 mL bacteriostatic water; inject slowly down the vial wall.
- Swirl gently until lyophilized powder dissolves fully.
- Final concentration: 5 mg/mL (10 mg / 2 mL). At 5 mg/mL: 1 unit = 50 µg.
- Label with date and 5 mg/mL notation; refrigerate at 2–8 °C.
Supplies needed
12-week plan
- 1 vial
- 12 syringes
- 2 mL bac water
- 12 alcohol swabs
20-week plan
- 1 vial
- 20 syringes
- 2 mL bac water
- 20 alcohol swabs
24-week plan
- 2 vials
- 24 syringes
- 4 mL bac water
- 24 alcohol swabs
Protocol overview & cycle notes
Provide an efficient 20+ week supply of cagrilintide from the 10 mg vial for patients advancing through the full 2.4 mg titration protocol, particularly when used as part of the CagriSema combination.
Cycle length: 20 weeks on.
Off-cycle: 8 weeks off; monitor weight and metabolic parameters.
Storage & handling
Injection & tracking tips
- At 5 mg/mL, units are halved compared to the 5 mg vial (2.5 mg/mL). The 2.4 mg maintenance dose is 48 units (not 96 units).
- The 10 mg vial provides approximately 4 maintenance doses at 2.4 mg — plan reconstitution every 4 weeks.
- Store vial upright in the refrigerator door; avoid temperature fluctuations from frequent door opening.
Tracking
Logging helps you and your provider spot patterns and adjust dose or timing.
- Track weekly body weight at the same time of day (fasted, morning).
- Record GI symptom severity using a 0–10 scale for the first 16 weeks.
- Monitor blood glucose weekly if using alongside semaglutide for the CagriSema protocol.
How this works & references
Sources
- REDEFINE-1 Phase 3 interim (NCT04982575) — CagriSema: 22.7% weight loss at 68 weeks
- Source: SCALE Phase 2 (NCT04755959) — 15.6% weight loss, CagriSema vs. components
Frequently asked questions
How does the 10 mg vial compare to the 5 mg vial for dosing accuracy?
How long does a 10 mg vial last at 2.4 mg/week maintenance?
Is CagriSema more effective than tirzepatide?
Can I use cagrilintide with tirzepatide instead of semaglutide?
What happens if I miss a weekly cagrilintide dose?
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View protocolThis content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.
Quickstart highlights
Cagrilintide 2.4 mg once weekly combined with semaglutide 2.4 mg (CagriSema) produced 22.7% body weight reduction at 68 weeks in the Phase 3 REDEFINE-1 interim analysis, surpassing both monotherapies.
- Concentration: 5 mg/mL (10 mg vial + 2 mL bacteriostatic water).
- At 5 mg/mL: 0.25 mg = 5 units, 0.5 mg = 10 units, 1 mg = 20 units, 2.4 mg = 48 units.
- REDEFINE-1 Phase 3: CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) produced 22.7% weight loss at 68 weeks.
- One 10 mg vial provides ~4 maintenance doses at 2.4 mg weekly.
- Refrigerate; use within 28 days.
Dosing table
For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.
| Week | Dose (µg) | Units | Frequency | Notes |
|---|---|---|---|---|
| 1-4 | 250 | 5 | Once weekly | 0.25 mg — 5 units at 5 mg/mL; one 10 mg vial provides 40 starting doses |
| 5-8 | 500 | 10 | Once weekly | 0.5 mg — 10 units |
| 9-12 | 1000 | 20 | Once weekly | 1 mg — 20 units |
| 13-16 | 1700 | 34 | Once weekly | 1.7 mg — 34 units |
| 17+ | 2400 | 48 | Once weekly | 2.4 mg maintenance — 48 units; 10 mg vial provides ~4 maintenance doses |
Your free Cagrilintide tracker
- Dose reminders
- Injection logging
- Cycle progress
Reconstitution steps
- Draw 2 mL bacteriostatic water; inject slowly down the vial wall.
- Swirl gently until lyophilized powder dissolves fully.
- Final concentration: 5 mg/mL (10 mg / 2 mL). At 5 mg/mL: 1 unit = 50 µg.
- Label with date and 5 mg/mL notation; refrigerate at 2–8 °C.
Supplies needed
12-week plan
- 1 vial
- 12 syringes
- 2 mL bac water
- 12 alcohol swabs
20-week plan
- 1 vial
- 20 syringes
- 2 mL bac water
- 20 alcohol swabs
24-week plan
- 2 vials
- 24 syringes
- 4 mL bac water
- 24 alcohol swabs
Protocol overview & cycle notes
Provide an efficient 20+ week supply of cagrilintide from the 10 mg vial for patients advancing through the full 2.4 mg titration protocol, particularly when used as part of the CagriSema combination.
Cycle length: 20 weeks on.
Off-cycle: 8 weeks off; monitor weight and metabolic parameters.
Storage & handling
Injection & tracking tips
- At 5 mg/mL, units are halved compared to the 5 mg vial (2.5 mg/mL). The 2.4 mg maintenance dose is 48 units (not 96 units).
- The 10 mg vial provides approximately 4 maintenance doses at 2.4 mg — plan reconstitution every 4 weeks.
- Store vial upright in the refrigerator door; avoid temperature fluctuations from frequent door opening.
Tracking
Logging helps you and your provider spot patterns and adjust dose or timing.
- Track weekly body weight at the same time of day (fasted, morning).
- Record GI symptom severity using a 0–10 scale for the first 16 weeks.
- Monitor blood glucose weekly if using alongside semaglutide for the CagriSema protocol.
How this works & references
Sources
- REDEFINE-1 Phase 3 interim (NCT04982575) — CagriSema: 22.7% weight loss at 68 weeks
- Source: SCALE Phase 2 (NCT04755959) — 15.6% weight loss, CagriSema vs. components
Frequently asked questions
How does the 10 mg vial compare to the 5 mg vial for dosing accuracy?
How long does a 10 mg vial last at 2.4 mg/week maintenance?
Is CagriSema more effective than tirzepatide?
Can I use cagrilintide with tirzepatide instead of semaglutide?
What happens if I miss a weekly cagrilintide dose?
Related protocols
KLOW Blend Dosing Protocol — BPC-157, TB-500, KPV & GHK-Cu Guide
KLOW peptide blend (BPC-157 + TB-500 + KPV + GHK-Cu) dosing guide for tissue repair, anti-inflammatory support, and extracellular matrix remodeling — the GLOW blend plus KPV.
View protocol
GLOW Blend Dosing Protocol — BPC-157, TB-500 & GHK-Cu Skin & Repair Guide
GLOW peptide blend (BPC-157 + TB-500 + GHK-Cu) dosing guide for tissue repair, angiogenesis, and collagen and connective-tissue remodeling.
View protocol
Vilon Dosing Protocol: 20 mg Vial — Dipeptide Immune & Longevity Bioregulator Guide
Vilon (Lys-Glu dipeptide) Russian immune and longevity bioregulator dosing guide — the simplest Khavinson bioregulator for systemic immune normalization and longevity support.
View protocol
Vesugen Dosing Protocol: 20 mg Vial — Vascular Bioregulator & Cardiovascular Guide
Vesugen (Lys-Glu-Asp tetrapeptide) Russian vascular bioregulator dosing guide — endothelial cell gene normalization for arterial health, blood pressure regulation, and cardiovascular aging.
View protocol
This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.