Delta Sleep-Inducing Peptide，促δ睡眠肽 DSIP

Delta Sleep-Inducing Peptide（Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu 九肽）：作用于下丘脑睡眠中枢增强慢波（δ）睡眠，并可调节应激轴与体温节律（确切受体机制尚未完全阐明，属在研多肽）

• 慢性失眠，• 嗜睡症，• 阿片戒断辅助治疗

Delta-sleep-inducing peptide (DSIP) is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

Its amino acid sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE). The gene has yet to be found in rabbits, along with any receptors or precursor peptides. However, searches through BLAST have found that it aligns with a hypothetical Amycolatopsis coloradensis protein. This could indicate that DSIP has a bacterial origin.

Source: English Wikipedia, "Delta-sleep-inducing peptide".

Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.

Roles in endocrine regulation Decreases basal corticotropin level and blocks its release.

Stimulates release of luteinizing hormone (LH). Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.

Roles in physiological processes Can act as a stress limiting factor.

May have a direct or indirect effect on body temperature and alleviating hypothermia.