FOXO4 干扰肽 FOXO4-DRI
理化性质
2460055-10-9
作用与功效
Senolytic (衰老细胞清除剂) / Senolytic 类 D-retro-inverso 肽：竞争性干扰 FOXO4 与 p53 的相互作用，解除对 p53 凋亡通路的滞留，选择性诱导停止分裂但持续分泌炎症因子的「僵尸细胞」凋亡
功效：靶向清除衰老细胞（Senolytics）；延缓器官老化、改善皮肤老化、减轻炎症衰老；仍以实验室研究为主，无临床合规注射方案。
干扰 FOXO4 与 p53 蛋白的相互作用，靶向诱导体内停止分裂但仍分泌炎症毒素的“僵尸细胞”凋亡，从而逆转系统层面的组织衰老。
英文详细资料 / Details (EN)
FOXO4-DRI is a synthetic peptide derivative that is described as an all D-enantiomer retro-inverso peptide It blocks the activity of Forkhead box protein O4 (FOXO4), a transcription factor which is elevated in senescent cells, and helps maintain their viability. Blocking FOXO4, which inhibits the activation of P53, causes senescent cells to undergo apoptosis by P53 activation, without affecting healthy cells around them, and has anti-aging effects which may have potential applications in the treatment of numerous age-related diseases, as well as an adjunct to treatment for certain forms of cancer.
It has the sequence H-ltlrkepaseiaqsileaysqngwanrrsggkrppprrrqrrkkrg-OH.
Source: English Wikipedia, "FOXO4-DRI".
功效：靶向清除衰老细胞（Senolytics）；延缓器官老化、改善皮肤老化、减轻炎症衰老；仍以实验室研究为主，无临床合规注射方案。
干扰 FOXO4 与 p53 蛋白的相互作用，靶向诱导体内停止分裂但仍分泌炎症毒素的“僵尸细胞”凋亡，从而逆转系统层面的组织衰老。