Modern Endocrine（Oklahoma City, OK）

Modern Endocrine, established in 2020 and based in Oklahoma City, Oklahoma, provides comprehensive telehealth endocrinology and functional medicine services across 43 states. Under the clinical direction of Dr. Cassie Smith, a board-certified internist credentialed by the American Board of Internal Medicine, the practice specializes in hormonal imbalances, metabolic dysfunction, thyroid disorders, and root-cause investigation of complex endocrine conditions. Dr. Smith integrates conventional endocrinology with functional medicine principles to address not only hormone optimization but also gut health, nutrient deficiencies, and systemic inflammation that often underlie metabolic and hormonal symptoms.

The clinic’s treatment protocols frequently incorporate peptide therapies tailored to individual metabolic and hormonal profiles, alongside comprehensive lab analysis that extends beyond standard endocrine panels. Patients receive detailed assessments of thyroid function including reverse T3 and thyroid antibodies, sex hormone panels with metabolite testing, cortisol rhythm analysis, and metabolic markers such as fasting insulin and hemoglobin A1c. Modern Endocrine’s approach emphasizes identifying underlying causes of symptoms rather than symptom suppression alone, which often involves evaluating gut microbiome health, chronic inflammation, and nutrient status as contributors to hormonal dysregulation. The practice treats conditions including hypothyroidism, Hashimoto’s thyroiditis, polycystic ovary syndrome, adrenal dysfunction, insulin resistance, perimenopause and menopause symptoms, and unexplained weight gain or fatigue.

Dr. Cassie Smith brings specialized training in internal medicine with focused expertise in endocrine disorders and metabolic health. Her clinical methodology combines evidence-based endocrinology with functional medicine diagnostics, allowing for treatment plans that address hormonal symptoms while investigating systemic factors such as intestinal permeability, micronutrient deficiencies, and chronic stress patterns. Patients benefit from her thorough interpretation of complex lab findings and her ability to explain the interconnections between thyroid function, sex hormones, metabolic health, and gastrointestinal wellness. The practice maintains a collaborative approach, with patients often reporting that Dr. Smith takes time to educate them on the physiological mechanisms behind their symptoms and the rationale for each intervention.

New patients begin with a comprehensive telehealth consultation that includes detailed symptom review, medication and supplement history, prior lab analysis, and discussion of health goals. Modern Endocrine coordinates lab testing through national networks accessible in patients’ local areas, with results reviewed in follow-up video appointments. Treatment plans may include bioidentical hormone replacement, thyroid medication optimization, peptide therapy protocols, targeted supplementation based on deficiency testing, and lifestyle modifications addressing sleep, stress management, and nutrition. The practice works with patients to navigate insurance coverage for lab work and consultations, though some advanced functional testing may require out-of-pocket payment. Follow-up frequency is individualized based on treatment complexity, with most patients seen every 8-12 weeks during active treatment phases.

With telehealth availability across 43 states, Modern Endocrine serves patients throughout the United States who seek specialized endocrine care without geographic limitations. The virtual care model allows for consistent provider continuity and eliminates travel barriers for patients in rural areas or those with mobility limitations. Oklahoma City serves as the practice’s administrative base, but patients access the same level of clinical expertise regardless of location. The clinic’s 4.8-star rating across 177 Google reviews reflects patient appreciation for thorough explanations, responsiveness to questions between appointments, and the depth of knowledge applied to complex hormonal cases. Modern Endocrine represents a model of accessible, specialized endocrine care that combines the precision of board-certified internal medicine with the investigative depth of functional medicine.