PTD-DBM
理化性质
1609454-11-6
作用与功效
Wnt/β-catenin 通路强效激活剂 / 抑制 CXXC5 与 Dishevelled 的结合、解除对 Wnt/β-catenin 通路的抑制：激活头皮干细胞与毛囊再生程序，常配合微针用于雄激素性脱发研究
通过抑制 CXXC5 蛋白解开毛囊再生的基因限制。直接作用于头皮干细胞，促发新毛发新生，常与微针结合用于治疗雄性激素脱发。
英文详细资料 / Details (EN)
Protein transduction domain-fused dishevelled binding motif (PTD-DBM) is a synthetic peptide which interacts with the mechanism of the hair loss-linked endogenous protein, CXXC5, which is a negative feedback regulator of the Wnt/β-catenin pathway. Application of the peptide to bald laboratory mice resulted in new hair follicle growth.
PTD-DBM is a peptide activating the Wnt/β-catenin signaling pathway functioning via interference of the binding of CXXC5 to dishevelled (Dvl), an upstream component of the Wnt/β-catenin pathway. By topical application, the PTD-DBM promotes the formation of new hair follicles and prevents hair loss. Combinatory treatment of PTD-DBM with valproic acid (VPA), the activator of Wnt/β-catenin pathway, further induce hair re-growth as well as wound-induced hair neogenesis (WIHN). The increased expression of CXXC5 in the bald scalps and excellent effects of PTD-DBM on hair growth in mice raised hopes for the application of this peptide on hair growth in the clinic.
Source: English Wikipedia, "PTD-DBM".
通过抑制 CXXC5 蛋白解开毛囊再生的基因限制。直接作用于头皮干细胞，促发新毛发新生，常与微针结合用于治疗雄性激素脱发。